鼠周围神经端侧缝合与侧侧缝合修复方式的比较研究

【英文篇名】Comparative studies of peripheral nerve repair mode between end to side neurorrhaphy and side to side neurorrhaphy in rates

【作者中文名】秦荣生; 李健宁; 钟延丰; 王盛兰; 郑菊阳; 马勇光; 薛宏宇; 李东; 王侠;

【作者英文名】QIN Rongsheng; LI Janning; ZHONG Yanfeng; et al. Department of Plastic Surgery; Third Hospital; Peking University; Beijing; 100083; China.;

【作者单位】北京大学第三医院成形外科研究中心; 北京大学病理学系; 北京大学第三医院神经内科; 北京大学第三医院成形外科研究中;

【文献出处】中华外科杂志, Chiese Journal of Surgery, 编辑部邮箱 2001年 02期

期刊荣誉：

【关键词】周围神经; 引导组织再生; 神经再生; 缝合技术;

【英文关键词】Peripheral nerves; Guided tissue regeneration; Nerve regeneration; Suture techniques;

【摘要】目的进一步探讨神经缝合修复方式对神经再生的影响。方法将SD鼠分为两组。端侧缝合组:将腓神经远侧断端与去外膜胫神经 (开窗 )行端侧缝合 ,开窗大小相当于腓神经的直径。侧 侧缝合组 :将腓神经远侧断段侧壁去除外膜 ,同样胫神经侧壁去外膜 ,两者去除外膜的面积相当于腓神经直径的 3倍。将去外膜的两神经干进行侧 侧缝合。通过足印分析法 ,组织学方法 ,电生理 ,神经纤维密度等测量。比较两种修复法神经再生质量。结果术后 16周时端 侧组和侧 侧组腓神经功能指数分别为 (- 39 92± 11 6 7)和 ( 6 4 49± 31 31) (P =0 0 33) ,有显著差异。电生理术后 16周侧 侧组腓神经潜伏期 (Lat) (1 17± 0 2 6 )、波幅 (Amp) (2 4 9± 3 5 9)优于端 侧组Lat(1 42±0 0 6 )、Amp(16 5± 7 0 4)。组织学检查显示侧 侧组神经纤维密度 (4 330± 6 72 )较端 侧组 (3186± 199)高。结论鼠类腓 胫神经侧 侧缝合对神经再生有益

【英文摘要】Objective To study the impact of nerve repair mode on reinnervation. Methods SD rates were divided into two groups: end to side group and side to side group. In the first group, the distal ending was sutured to the lateral wall of tibial nerve with removal of the epineurial sheath. The area of removed sheath was same as that of peroneal nerve cross section. In the side to side group, the lateral side of distally severed peroneal nerve trunk with removal of the epineurium was sutured to the tibial n…